GG in COMT's Val/Met variation, meaning Val/Val , or warrior , higher activity of the COMT enzyme and quicker breakdown of dopamine. Individuals with this have advantages in stress resilience but disadvantages in attention tasks.
GG in COMT's rs6267, which is the typical for most humans and leads to slightly lower risk of Schizophrenia
GG, which means no derived No-Go Learner variants in DRD2's Pro319Pro variation, which means a higher number of D2 receptor sites in the brain, and a higher likelihood of schizophrenia
GG in rs4648317 of DRD2, which is the typical for most humans, and leads to a slightly lower risk of Schizophrenia and nicotine dependence.
AA in Taq1 variation of DRD2, which is implicated in a greatly decreased number of Dopamine D2 receptor sites in the brain and an increased likelihood of Alcoholism, Parkinson's, ADHD, and various other illnesses. This is not a typical human .
AA in rs1076560 of DRD2, which is implicated in a decreased number of Dopamine D2 receptor sites in the brain and an increased likelihood of Alcoholism as well as decreased memory function. This is not a typical human .
CC in rs5326 of DRD1, which is the typical for most humans and leads to a slightly lower risk of various mental health conditions.
GG in rs686 of Dopamine Receptor D1 gene, which is the typical and leads to lower likelyhood of autism.
AA in rs265981 of DRD1, which is implicated in decreased risk of various mental health issues. This is most typical for Europeans.
TT in rs6280 of DRD3, a typical associated with a slightly lower risk of OCD and intellectual disability.
AA in rs11246226 of DRD4, which is implicated in a higher likelyhood of Schizophrenia.
CC in rs1800955 of DRD4, a associated with an increased likelyhood of multiple mental health conditions, including novelty seeking, addiction and intellectual disability.
TT in DRD5's rs6283. Lower odds of ADHD; mechanism of action is not exactly known
TT in rs2129785, a typical for most humans. The implications of this is that this individual does not have long form 5-HTTLPR and does not have a decrease in the risk of depression.
CC in rs6311 of HTR2A, robustly increased risk of suicidal behavior and depression. 3.6x increased risk of sexual dysfunction when taking SSRI Antidepressants
GG in rs75459873, no risk variants for psychosis in MIR378F. Very typical genotype.
Homozygous major allele at ADCY2 gene. Associated with decreased bipolar risk.
Results Mental Health - Autism Only
CC in rs4307059, Reduced Autism risk
TT in rs10513025, typical , normal (higher) risk of autism.
AA in rs7794745, slightly decreased risk of autism.
CC in rs1858830, 2x risk of autism reported by some (but not other) publications.
CC in rs1804197, common genotype. Normal (lower) risk of autism.
TT in rs921451, More likely to smoke heavily if is a smoker.
TT in rs1451371, More likely to smoke heavily if is a smoker.
Results For Lactose Persistence
GG in MCM6's rs4988235 variation, which means this individual does not carry the European lactose persistence mutation.
Results for OXTR - The Empathy Gene
AG in OXTR's rs53576 variation, which means this individual has 1 sociopath variant for reduced OXTR expression and lack of empathy together with 1 variant for higher levels of empathy.
GG in rs1042778 of OXTR, higher oxytocin and empathy
TT in OXTR's rs13316193, a associated with decreased OXTR expression and lower levels of empathy, as well as higher risk of autism spectrum disorder.
Results for Diabetes
GG in rs12255372, decreased risk of Type 2 Diabetes.
GG in rs35011184, lower odds of Type 2 diabetes and obesity.
CC in rs9273363, which leads to a 7 fold decrease in the risk of type 1 diabetes.
CC in rs7903146, a associated with lower risk of type 2 diabetes.
TT in rs4402960,leading to a significant increase in the risk of Type 2 Diabetes.
Results for Hemochromatosis
GG in HFE's Cys282Tyr variation, which means this individual is not a carrier for the C282Y hemochromatosis mutation.
CC in HFE's His63Asp, which means this individual does not have any H63D variants and most likely doesn't have hemochromatosis.
AA in HFE's S65C variation, which means that this individual does not carry any risk variants for hemochromatosis.
Results for Alzheimers
CC in rs7412, which means no APOE2 alleles in Arg176Cys variation of the APOE gene and lower, or in other terms, normal odds of alzheimers disease.
TT in rs429358, no risk alleles for Alzheimers in this APOE variation.
TT in rs3025786, which is a typical for most humans and leads to average (slightly increased) risk of Alzheimers.
GG in PLD3's rs145999145 variation, which means this individual has a lower risk of Alzheimers.
TT in rs669, which leads to slightly decreased risk of Alzheimers.
AA in TOMM40's rs2075650, slightly decreased odds of Alzheimer's disease.
Multiple sclerosis
(Linked) likely no HLA-DRB1*1501 alleles, typical , normal (lower) risk for MS.
no HLA-DRB1*1501 alleles, typical , normal (lower) risk for MS.
AA in rs4959039, 2 (common) risk variants for MS.
Cardio-Vascular Disease Panel
AA in rs662799, normal (Lower odds of heart attack and obesity)
AA in rs700651, normal (lower) risk of aneurysm
GG in rs10958409, normal (lower) risk of brain aneurysm, risk allele is A
CC in rs1333040, lower odds of brain aneurysm and heart attack, risk allele is T.
AA in rs9298506, normal (higher) risk of aneurysm.
CC in rs6475606, much lower risk of Coronary artery disease.
CC in rs10757272, Normal (lower) risk for Coronary artery disease.
CC in rs9315204, lower risk of aneurysm, common genotype.
AA in rs10757274, normal(lower) risk of heart disease.
GG in rs2383206, 1.7x increased risk for heart disease.
AA in rs10757278, 0.78x reduced risk for Coronary Heart Disease. 0.77x reduced risk for Brain Aneurysm and Abdominal Aortic Aneurysm..
AG in rs17576, average odds of heart attack and lung cancer.
Myopia Panel (Ordered from highest to lowest impact)
AA in rs12193446, which is the typical and leads to slightly increased risk of myopia, or nearsightedness.
CC in rs7744813, which leads to an increase in the risk of myopia.
CC in rs4803455, two alleles for increased Myopia risk.
GG in RBFOX1's rs17648524, two alleles that protect against myopia.
CC in rs3138142, higher odds of myopia.
Miscellaneous
(Don't voice this in video!!) CC in rs9332964, no micropenis.
TT in rs28379706, lower IQ.
GG in rs324640, 8 points higher IQ than individuals with 'AA' .
CC in rs1815739, Better performing muscles. Likely sprinter.
TT , No 'fat gene' variants in FTO's rs9939609.
TT in rs10427255, likely does not have photic sneeze reflex.
GG in SCN9A rs6746030 variation, no variants for increased pain sensitivity.
AA genotype in EDAR's rs3827760, Likely no shovel shaped incissors and not East Asian in ancestry
GG in rs671 variation, Not an Asian flusher, lower odds of Alcoholism. Normal risk of Esophageal Cancer.
AG in rs1080066, larger brain volume. Rare .
Drug Responce
When treated with metoprolol
rs1801252(A;A) and rs1801253(C;C) carriers: 15 point drop in Blood Pressure rs1801252(A;G) and rs1801253(C;C) carriers: 9 point drop in Blood Pressure rs1801252(A;A) and rs1801253(C;G) carriers: 6 point drop in Blood Pressure rs1801252(A;G) and rs1801253(C;G) carriers: 1 point drop in Blood Pressure
Your genotypes are : &
CC in rs1467558, lower (normal) risk of liver toxicity from acetominophen/tylenol/APAP
TT in rs12476047. Lower than average odds of parkinson's symptoms when treated with antipsychotics
CC in rs5092, significantly less likely to gain weight if taking olanzapine.
CC in rs4765623, significantly more likely to gain weight if taking olanzapine.
GG in rs518147, significantly higher odds of weight gain if taking olanzapine.
CC in AKT1's rs2494732, greater odds of cannabis-associated psychosis.
GG in rs2241802, higher odds of methamphatamine induced psychosis.
CC in rs135745, higher susceptibility to methamphetamine induced psychosis.
Albinism & Atypical Traits Panel
CC in OCA2's rs121918166, Not Carrier of an oculocutaneous Albinism Type II mutation.
AA in TYR's rs28940881 variation, which means this individual does not have any Tyrosinase-negative oculocutaneous albinism mutations.
AA in TYR's rs28940878 variation, which means this individual does not have any Tyrosinase-negative oculocutaneous albinism mutations.
TT in rs61754381, which means not a carrier for 1B Tyrosinase-negative oculocutaneous albinism.
CC in TYR's rs104894313, Not Carrier of an oculocutaneous Albinism Type 1B mutation.
CC in TYRP1's rs104894130, which means this individual lacks variants for Oculocutaneous albinism type 3, and is not albino.
CC in TYRP1's rs387907171, not a Carrier of melanesian blond hair variants.
Familiar Mediterranean Fever Panel
0 risk variants in rs104895094.
0 risk variants in rs61752717
0 risk variants in rs28940579.
0 risk variants in rs28940578.
0 risk variants in rs61732874.
0 risk variants in rs104895097.
0 risk variants in rs104895085
0 risk variants in rs104895157
0 risk variants in rs11466024
0 risk variants in rs79681911
0 risk variants in rs4149584
MTHFR panel
AA in rs17367504, common , average (higher) blood pressure.
Cancers Panel
0 risk variants in S1140G of BRCA1
2 risk variants in S1613G of BRCA1
1 risk variant in N372H of BRCA2.
0 risk variants in S707P
AA in rs4474514, >3x increased testicular cancer risk for men
Leukemia Panel
TT in rs4132601, common -> lower risk of leukemia.
TT in rs7089424, common/normal and lower risk of Leukemia.
AA in rs2239633, lower odds of leukemia (~0.7x).
GG in rs662463, common , lower odds of leukemia.
Rare diseases/traits Panel
CC in rs2200733, 0.86x decreased risk of Atrial Fibrillation
CC in rs7743761, Normal (lower) risk of Ankylosing Spondylitis.
GG in rs13078881, Healthy - no Biotinidase deficiency.
TT in rs6151429, healthy
GG in rs104894637 - not a carrier for Sanfilippo syndrome risk
CC in rs104894635, no risk variants for Sanfilippo syndrome
CC in rs1800546, normal.
TT in rs74315405, no Gerstmann–Straussler–Scheinker syndrome.
GG in rs11606250, most common , but higher risk for certain autoimmune diseases.
CC, 2 risk variants in rs2302009. 4.6x higher odds of eosinophilic esophagitis
Celiac Disease Panel
average, no HLA-DRB1*0301 alleles, normal risk of celiac disease and lupus.
2 risk variants in CCR3
No risk variants in IL18R1
AA in rs13119723, lower (normal) risk for celiac disease. 0 risk variants
No risk variants in R262W
Allergies Panel
CC in rs17513503, lower odds of allergies; common
GT in rs7192, somewhat (1.7x) increased risk of developing a peanut allergy. Risk variant is T.
Androgen Receptor Gene (AR) Panel
CC in rs137852591, very typical ; no Androgen insensitivity.
GG in rs9332969, normal , no Reifenstein syndrome.
Crohn's Disease Panel
CC in NOD2's Arg702Trp. Typical (lower) risk for Crohn's disease.
GG in rs2066845, normal (lower) risk for Crohn's disease. Risk allele is C.
Canavan Syndrome Panel
GG in rs104894553, 0 risk variants.
0 risk variants in A305E.
If you have more than 0 risk variants for Canavan syndrome, that is cause for concern. May be the result of genotyping errors depending on the chip you tested with.
HIV & AIDS Panel
HIV does not develop and transition into AIDs the same way with every organism. Some are predisposed to larger viral load and quicker compromisation of the immune system while others are more resistant.
0 protective variants in C927T (Bad), most typical genotype.
common (Good), no risk variants in rs2395029 (TT )
Muscular Dystrophy Myopathies
0 risk variants in rs121913574
0 risk variants for Duchenne muscular dystrophy in rs1800278
0 risk variants in rs28937903
0 risk variants in rs28937904
0 risk alleles in rs2296949
Found : 0 risk variants for adrenoleukodystrophy out of 24 Total
If you have risk variants here, it is most likely caused by miscalls in your raw data.
Since ADL is an X-linked condition, males can not be carriers. If you are male over the age of 20 and see risk variants here, it is due to miscalls. Otherwise you would be dead.
Colorblindness Panel
0 risk variants in OPN1LW out of 4
0 risk variants in OPN1MW out of 4
0 risk variants in OPN1SW out of 6
FTO Gene Panel
No risk variants for obesity in rs9930506, lower risk of obesity
No fat gene variants in rs11642015, lower odds of obesity
GG in rs1121980, lower BMI, decrease in the risk of obesity
TT , No 'fat gene' variants in FTO's rs9939609.
Within PFKP Gene - also implicated in Obesity
AA in rs6602024, much higher BMI
Others also implicated in Obesity
AA in rs4994, typical genotype - lower odds of obesity.
CC in rs1799883, This genotype is not associated with increased sensitivity to saturated fats or refined carbohydrates.
Syncope Panel
A syncope, commonly known as fainting, is a temporary loss of consciousness and muscle tone caused by a brief reduction in blood flow to the brain. This sudden and temporary loss of consciousness typically results from a drop in blood pressure, leading to a momentary interruption of oxygen and nutrient supply to the brain. Syncope episodes are often brief, lasting only a few seconds to a couple of minutes, and individuals usually recover spontaneously once blood flow is restored. Various factors, such as dehydration, low blood sugar, or sudden changes in body position, can contribute to the occurrence of syncope.
CC in rs12465214 of ZNF804A, increased odds of Syncope. Odds ratio of ~1.1, this is the lowest pval (most statistically significant) snp for syncope risk
AA in rs1431318, around 7% increase in the risk of syncope.
Used 5 snps in the following prediction
Syncope risk is 0.985 times the average
Bio Traits Panel
TT in rs6047844, higher risk of male pattern baldness.
TT in rs2148710, higher predisposition to anger
Two copies of "farmer" CLTCL1 gene variant. has a selective advantage in processing carbohydrate-rich diets (presumably including those with lots of sugar)
AA in rs660895, decreased risk of rheumatoid arthritis. Slightly decreased risk of IgA nephropathy - a disease in which IgA protein builds up in and damages the filtering part of the kidney (glomerulus)
CC in rs307377, common in complete genomics - no extraordinary tasting ability
GG in rs547154, no increased protection from Age-related maculopathy, most typical genotype.
CC in rs1061147, Reduced 0.34x risk of Age Related Macular Degeneration.
AA in rs662799, normal (Lower odds of heart attack and obesity)
GG in rs2282679 of GC gene, typically lower levels of Vitamin D.
TG in rs12785878, likely lower levels of Vitamin D.
AA in rs10741657, tend to have higher vitamin D levels
CC in rs6544713, slightly lower LDL cholesterol
CC in rs27072, 2x risk of severe alcohol withdrawal. Possible increased odds of ADHD
TT in rs10047474, increased blood pressure
GG in rs4961 (imputed through rs4963), lower blood pressure
DVT Panel
CC in rs11121615, higher odds of varicose veins. Highest pval and beta snp for this trait
CC in rs6025, lower (normal) risk of deep vein thrombosis
AA in rs7654093, slightly lower odds of deep vein thrombosis
Blood Group Panel
CC in rs635634, higher odds for all blood types besides A. 0.92 accuracy
CC in rs8176720, not blood type A or O. 0.77 accuracy
GG in rs7030248, Likely no Blood type B or AB. Accuracy 0.74
TT in rs493014, no blood type B or AB. Accuracy 0.75.
GG in rs687289, Likely not Blood type AB. Accuracy 0.91
TT in rs505922, Likely blood type O. 0.8 accuracy
TT in rs529565, Likely blood type O. 0.98 accuracy
TT in rs8176740, higher odds of B and O blood types
